Impaired import: how huntingtin harms

Name: Impaired import: how huntingtin harms
Creator: Elizabeth A, Jonas
Keywords: Male, Mitochondrial Proteins, 0301 basic medicine, Huntingtin Protein, 0303 health sciences, 03 medical and health sciences, Huntington Disease, Animals, Humans, Female

Elizabeth A, Jonas

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Nature Neuroscience

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Nature Neuroscience

Article . 2014 . Peer-reviewed

License: Springer TDM

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Nature Neuroscience

Article . 2014

Data sources: Europe PubMed Central

https://dx.doi.org/10.1038/nn....

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Impaired import: how huntingtin harms

descriptionPublicationkeyboard_double_arrow_right Article 27 May 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Neuroscience, volume 17, pages 747-749 (issn: 1097-6256, eissn: 1546-1726,

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Authors: Elizabeth A, Jonas;

doi: 10.1038/nn.3726

pmid: 24866036

pmc: PMC4448962

Impaired import: how huntingtin harms

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Abstract

We now learn that mutant huntingtin binds to a complex that imports constituent proteins across the mitochondrial inner membrane, halting bioenergetics in synaptic mitochondria and predisposing to neuronal dysfunction and death.

Related Organizations

Yale University
United States

Keywords

Male, Mitochondrial Proteins, Huntingtin Protein, Huntington Disease, Animals, Humans, Female, Nerve Tissue Proteins

6 Research products, page 1 of 1

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
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Erratum: Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity
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Inhibition of DNA Methyltransferases Blocks Mutant Huntingtin-Induced Neurotoxicity
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Identification of the DEAD-box protein DDX24 as a novel modulator of Huntingtin induced caspase activation
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The Melatonin MT1 Receptor Axis Modulates Mutant Huntingtin-Mediated Toxicity
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Inhibition of mitochondrial protein import by mutant huntingtin
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Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	9
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average