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DGIdb: mining the druggable genome

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 13 Oct 2013 English Publisher:Springer Science and Business Media LLCJournal:Nature Methods, volume 10, pages 1,209-1,210 (issn: 1548-7091, eissn: 1548-7105, Copyright policy )Funded by:NIH | Large Scale Genome Sequen...
Authors: Malachi Griffith; Obi L Griffith; Adam C Coffman; James V Weible; Josh F McMichael; Nicholas C Spies; James Koval; +16 Authors

doi: 10.1038/nmeth.2689

pmid: 24122041

pmc: PMC3851581

DGIdb: mining the druggable genome

Abstract

The Drug-Gene Interaction database (DGIdb) mines existing resources that generate hypotheses about how mutated genes might be targeted therapeutically or prioritized for drug development. It provides an interface for searching lists of genes against a compendium of drug-gene interactions and potentially 'druggable' genes. DGIdb can be accessed at http://dgidb.org/.

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Keywords

Genome, Lung Neoplasms, Computational Biology, Genetic Variation, Antineoplastic Agents, Breast Neoplasms, Genomics, Article, Gene Expression Regulation, Databases, Genetic, Drug Discovery, Mutation, Data Mining, Humans, Technology, Pharmaceutical, Drug Interactions, Software

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 470
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 0.1%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 0.1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
470
Top 0.1%
Top 1%
Top 0.1%
Green
hybrid
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