The biology of VEGF and its receptors
Copyright policy )The biology of VEGF and its receptors
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions. VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions. The biological effects of VEGF are mediated by two receptor tyrosine kinases (RTKs), VEGFR-1 and VEGFR-2, which differ considerably in signaling properties. Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies. VEGF inhibition is also being tested as a strategy for the prevention of angiogenesis, vascular leakage and visual loss in age-related macular degeneration.
- GENENTECH INC United States
Vascular Endothelial Growth Factor A, Clinical Trials as Topic, Lymphokines, Neovascularization, Pathologic, Vascular Endothelial Growth Factors, Neovascularization, Physiologic, Endothelial Growth Factors, Oxygen, Receptors, Vascular Endothelial Growth Factor, Animals, Humans, Intercellular Signaling Peptides and Proteins, Protein Isoforms, Endothelium, Vascular, Growth Substances, Signal Transduction
Vascular Endothelial Growth Factor A, Clinical Trials as Topic, Lymphokines, Neovascularization, Pathologic, Vascular Endothelial Growth Factors, Neovascularization, Physiologic, Endothelial Growth Factors, Oxygen, Receptors, Vascular Endothelial Growth Factor, Animals, Humans, Intercellular Signaling Peptides and Proteins, Protein Isoforms, Endothelium, Vascular, Growth Substances, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9K popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.01% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 0.01% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 0.01%
Citations provided by BIP!Popularity provided by BIP!