Endoplasmic reticulum stress and atherosclerosis
Copyright policy )Endoplasmic reticulum stress and atherosclerosis
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
- Harvard University United States
Inflammation, Macrophages, Apoptosis, Atherosclerosis, Endoplasmic Reticulum, Lipid Metabolism, Stress, Physiological, Unfolded Protein Response, Animals, Humans
Inflammation, Macrophages, Apoptosis, Atherosclerosis, Endoplasmic Reticulum, Lipid Metabolism, Stress, Physiological, Unfolded Protein Response, Animals, Humans
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