Proteases, proteases and proteases for presentation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Apr 2003 Netherlands English Publisher:Springer Science and Business Media LLCJournal:Nature Immunology, volume 4, pages 306-308 (issn: 1529-2908, eissn: 1529-2916,

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Authors: Herberts, Carla; Reits, Eric; Neefjes, Jacques;

doi: 10.1038/ni0403-306

Proteases, proteases and proteases for presentation

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Abstract

Peptide epitope generation for MHC class I presentation is normally dependent upon proteasome activity. Yet this pathway fails to generate critical HIV epitopes. Instead, the protease TPPII is required for this activity.

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Netherlands

Related Organizations

Antoni van Leeuwenhoek Hospital
Netherlands
Amsterdam UMC
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Netherlands Heart Institute
Netherlands

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