A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice
Copyright policy )A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice
Stratifin (Sfn, also called 14-3-3sigma) is highly expressed in differentiating epidermis and mediates cell cycle arrest. Sfn is repressed in cancer, but its function during development is uncharacterized. We identified an insertion mutation in the gene Sfn in repeated epilation (Er) mutant mice by positional cloning. Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice.
- Harvard University United States
- Kimmel Cancer Center United States
- Dana-Farber Cancer Institute United States
- Wadsworth Center United States
- New York State Department of Health United States
Exonucleases, Male, Heterozygote, Skin Neoplasms, Molecular Sequence Data, Alopecia, Hair Removal, Mice, Mutant Strains, Neoplasm Proteins, Mice, Phenotype, 14-3-3 Proteins, Epidermal Cells, Exoribonucleases, Mutation, Biomarkers, Tumor, Animals
Exonucleases, Male, Heterozygote, Skin Neoplasms, Molecular Sequence Data, Alopecia, Hair Removal, Mice, Mutant Strains, Neoplasm Proteins, Mice, Phenotype, 14-3-3 Proteins, Epidermal Cells, Exoribonucleases, Mutation, Biomarkers, Tumor, Animals
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