Dicer is essential for mouse development
Copyright policy )Dicer is essential for mouse development
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
- Kettering University United States
- Baylor College of Medicine United States
- Cold Spring Harbor Laboratory United States
- Howard Hughes Medical Institute United States
- Watson School of Biological Sciences United States
Mice, Knockout, Ribonuclease III, Stem Cells, Molecular Sequence Data, DEAD-box RNA Helicases, Embryonic and Fetal Development, Mice, Endoribonucleases, Animals, RNA Interference, Amino Acid Sequence, RNA Helicases
Mice, Knockout, Ribonuclease III, Stem Cells, Molecular Sequence Data, DEAD-box RNA Helicases, Embryonic and Fetal Development, Mice, Endoribonucleases, Animals, RNA Interference, Amino Acid Sequence, RNA Helicases
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