Name: Somatic and germline genetics at the JAK2 locus
Creator: Peter J. Campbell
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, Haplotypes, Hematologic Neoplasms, Chromosome Mapping, Humans, Janus Kinase 2, Germ-Line Mutation, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2009 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 41, pages 385-386 (issn: 1061-4036, eissn: 1546-1718,

Authors: Peter J. Campbell;

doi: 10.1038/ng0409-385

pmid: 19338077

Somatic and germline genetics at the JAK2 locus

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Abstract

Myeloproliferative neoplasms are hematological malignancies frequently associated with somatically acquired mutation of the JAK2 gene. A new study shows that these mutations are preferentially found within a particular inherited JAK2 haplotype, implying the existence of a strong, but uncharacterized, interaction between somatic and germline genetics at this locus.

Related Organizations

Wellcome Sanger Institute
United Kingdom
Wellcome Trust
United Kingdom

Keywords

Haplotypes, Hematologic Neoplasms, Chromosome Mapping, Humans, Janus Kinase 2, Germ-Line Mutation

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