Epigenetic variation and cellular Darwinism

descriptionPublicationkeyboard_double_arrow_right Article 27 Jul 2011 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 43, pages 724-726 (issn: 1061-4036, eissn: 1546-1718,

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Authors: Jean-Pierre Issa;

doi: 10.1038/ng.897

Epigenetic variation and cellular Darwinism

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Abstract

The human genome contains large areas with hypervariable DNA methylation that are associated with deregulation of gene expression. This epigenetic variation may be necessary for differentiation, but it also provides a mechanism for Darwinian evolution at the cellular level that may underlie age-related diseases such as cancer.

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The University of Texas MD Anderson Cancer Center
United States

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