Genetic loci influencing kidney function and chronic kidney disease
Copyright policy )Genetic loci influencing kidney function and chronic kidney disease
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10 10 to 10 15). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 × 10 5 and P = 3.6 × 10 4, respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
- University of Lausanne Switzerland
- Amsterdam UMC Netherlands
- National Institutes of Health United States
- Queen Mary University of London United Kingdom
- University of Oxford United Kingdom
Genetic Markers, Genotype, 610, Kidney, OCT2, Kidney Failure, Genetic, Models, Humans, Genetic Predisposition to Disease, Chronic, Cystatin C, oct2, genetic predisposition to disease, Models, Genetic, Genetic Variation, Biological Transport, Europe, Gene Expression Regulation, Creatinine, genome-wide association studies, Kidney Failure, Chronic, chronic kidney disease, Genome-Wide Association Study, Glomerular Filtration Rate
Genetic Markers, Genotype, 610, Kidney, OCT2, Kidney Failure, Genetic, Models, Humans, Genetic Predisposition to Disease, Chronic, Cystatin C, oct2, genetic predisposition to disease, Models, Genetic, Genetic Variation, Biological Transport, Europe, Gene Expression Regulation, Creatinine, genome-wide association studies, Kidney Failure, Chronic, chronic kidney disease, Genome-Wide Association Study, Glomerular Filtration Rate
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