Mismatch repair prefers exons

descriptionPublicationkeyboard_double_arrow_right Article 29 Nov 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 49, pages 1,673-1,674 (issn: 1061-4036, eissn: 1546-1718,

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Authors: Dashiell J, Massey; Amnon, Koren;

doi: 10.1038/ng.3993

pmid: 29186127

Mismatch repair prefers exons

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Abstract

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

Related Organizations

Cornell University
United States

Keywords

Mutation Rate, Mutation, Exons, DNA Mismatch Repair, Introns

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