Transposase-driven rearrangements in human tumors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 49, pages 975-977 (issn: 1061-4036, eissn: 1546-1718,

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Authors: Stephen C, Mack; Hiromichi, Suzuki; Michael D, Taylor;

doi: 10.1038/ng.3908

pmid: 28656983

Transposase-driven rearrangements in human tumors

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Abstract

A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.

Related Organizations

Cleveland Clinic
United States
Hospital for Sick Children
Canada

Keywords

Neoplasms, Humans, Transposases

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