ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

descriptionPublicationkeyboard_double_arrow_right Article 28 Apr 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Genetics, volume 46, pages 421-422 (issn: 1061-4036, eissn: 1546-1718,

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Authors: Gelareh Zadeh; Kenneth Aldape;

doi: 10.1038/ng.2970

ACVR1 mutations and the genomic landscape of pediatric diffuse glioma

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Abstract

Pediatric diffuse gliomas are rare but aggressive brain tumors for which effective therapies are unavailable. New studies identify recurrent mutations of the ACVR1 gene in these tumors, identify molecular subtypes and highlight differences between gliomas affecting children and adults.

Related Organizations

University of Toronto
Canada
The University of Texas MD Anderson Cancer Center
United States

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