Prevalence of sexual dimorphism in mammalian phenotypic traits
Copyright policy )Prevalence of sexual dimorphism in mammalian phenotypic traits
AbstractThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
- UNIVERSITE DE STRASBOURG France
- University of California, Berkeley United States
- INST NATIONAL SANTE RECHERCHE MEDICALE France
- UNIVERSITY OF CALIFORNIA United States
- University of Southern Denmark Denmark
570, Genotype, Science, Biological Psychology, 610, [SDV.GEN] Life Sciences [q-bio]/Genetics, Article, Quantitative Trait, Mice, Quantitative Trait, Heritable, Medicine and Health Sciences, Genetics, Psychology, 2.1 Biological and endogenous factors, Animals, Modifier, Heritable, Mammals, Sex Characteristics, Genes, Modifier, Biomedical and Clinical Sciences, Q, Body Weight, Life Sciences, Biological Sciences, Estrogen, Phenotype, Genes, Women's Health, Female, Generic health relevance, International Mouse Phenotyping Consortium, Infection
570, Genotype, Science, Biological Psychology, 610, [SDV.GEN] Life Sciences [q-bio]/Genetics, Article, Quantitative Trait, Mice, Quantitative Trait, Heritable, Medicine and Health Sciences, Genetics, Psychology, 2.1 Biological and endogenous factors, Animals, Modifier, Heritable, Mammals, Sex Characteristics, Genes, Modifier, Biomedical and Clinical Sciences, Q, Body Weight, Life Sciences, Biological Sciences, Estrogen, Phenotype, Genes, Women's Health, Female, Generic health relevance, International Mouse Phenotyping Consortium, Infection
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