Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
Copyright policy )Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin
AbstractThe connection between innate and adaptive immunity is best exemplified by antigen presentation. Although antigen-presenting cells (APCs) are required for antigen receptor-mediated T-cell activation, how T-cells feedback to APCs to sustain an antigen-specific immune response is not completely clear. Here we show that CD8+T-cell (also called cytotoxic T lymphocytes, CTL) feedback activates the NLRP3 inflammasome in APCs in an antigen-dependent manner to promote IL-1β maturation. Perforin from antigen-specific CTLs is required for NLRP3 inflammasome activation in APCs. Furthermore, such activation of NLRP3 inflammasome contributes to the induction of antigen-specific antitumour immunity and pathogenesis of graft-versus-host diseases. Our study reveals a positive feedback loop between antigen-specific CTLs and APC to amplify adaptive immunity.
- Cleveland Clinic United States
- Chinese Academy of Sciences China (People's Republic of)
- Shanghai Institutes for Biological Sciences China (People's Republic of)
- Shanghai Institute of Nutrition and Health China (People's Republic of)
- Center for Excellence in Molecular Cell Science China (People's Republic of)
Cytotoxicity, Immunologic, Inflammasomes, Science, Interleukin-1beta, Graft vs Host Disease, Bone Marrow Cells, Adaptive Immunity, Article, Mice, Cell Line, Tumor, Neoplasms, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Bone Marrow Transplantation, Mice, Knockout, Mice, Inbred BALB C, Perforin, Q, Dendritic Cells, Mice, Inbred C57BL, Disease Models, Animal, T-Lymphocytes, Cytotoxic
Cytotoxicity, Immunologic, Inflammasomes, Science, Interleukin-1beta, Graft vs Host Disease, Bone Marrow Cells, Adaptive Immunity, Article, Mice, Cell Line, Tumor, Neoplasms, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Humans, Bone Marrow Transplantation, Mice, Knockout, Mice, Inbred BALB C, Perforin, Q, Dendritic Cells, Mice, Inbred C57BL, Disease Models, Animal, T-Lymphocytes, Cytotoxic
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