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Lock and key become flexible

Name: Lock and key become flexible
Creator: Marc Baldus
Keywords: Taverne, Databases, Genetic, Humans, Kinins, 6. Clean water, Protein Binding, Receptors, G-Protein-Coupled, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 14 Feb 2018 Netherlands English Publisher:Springer Science and Business Media LLCJournal:Nature Chemical Biology, volume 14, pages 201-202 (issn: 1552-4450, eissn: 1552-4469,

Authors: Marc Baldus;

doi: 10.1038/nchembio.2567

pmid: 29443979

Lock and key become flexible

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Abstract

G-protein-coupled receptors (GPCRs) are critically involved in signal transduction. Structural views of several GPCRs have recently been obtained, but the structural principles determining subtype selectivity are still mostly elusive. Now, a combined solid-state NMR and molecular-modeling approach reveals how bradykinin GPCRs distinguish between closely related peptide ligands.

Country

Netherlands

Related Organizations

Utrecht University
Netherlands

Keywords

Taverne, Databases, Genetic, Humans, Kinins, Protein Binding, Receptors, G-Protein-Coupled

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	5
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average