Endoglin moves and shapes endothelial cells

descriptionPublicationkeyboard_double_arrow_right Article 31 May 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 593-595 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Victoria L, Bautch;

doi: 10.1038/ncb3543 , 10.17615/06n4-d198

pmid: 28561054

Endoglin moves and shapes endothelial cells

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Abstract

Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand-receptor signalling and flow-mediated mechanical cues.

Related Organizations

University of North Carolina at Chapel Hill
United States

Keywords

Cell Movement, Transforming Growth Factor beta, Bone Morphogenetic Proteins, Endoglin, Animals, Endothelial Cells, Humans, Cell Shape, Signal Transduction

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