Terminating the replication helicase

descriptionPublicationkeyboard_double_arrow_right Article 27 Apr 2017Embargo end date: 22 Nov 2017 United Kingdom English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 410-412 (issn: 1465-7392, eissn: 1476-4679,

Copyright policy )Funded by:WT | unidentified

Authors: Gaggioli, Vincent; Zegerman, Philip;

doi: 10.1038/ncb3519 , 10.17863/cam.10177

pmid: 28446815

pmc: PMC7610976

Terminating the replication helicase

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Abstract

A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

Country

United Kingdom

Related Organizations

University of Cambridge
United Kingdom
Wellcome / CRUK Gurdon Institute
United Kingdom
Wellcome Trust
United Kingdom

Keywords

Adenosine Triphosphatases, DNA Replication, Ubiquitin, DNA Helicases, Cell Cycle Proteins

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