G1 cyclins protect pluripotency

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2017 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 149-150 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Julia, Arand; Julien, Sage;

doi: 10.1038/ncb3480

pmid: 28248303

pmc: PMC6996865

G1 cyclins protect pluripotency

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Abstract

G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

Related Organizations

Stanford University
United States
Stanford Medicine
United States

Keywords

Pluripotent Stem Cells, Mice, Cyclin G1, Cytoprotection, Cell Cycle, Animals, Mouse Embryonic Stem Cells, Models, Biological, Cyclin-Dependent Kinases

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