Y chromothripsis?

descriptionPublicationkeyboard_double_arrow_right Article 23 Dec 2016 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 19, pages 12-14 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Emily M, Hatch;

doi: 10.1038/ncb3458

pmid: 28008180

Y chromothripsis?

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Abstract

Micronucleation of missegregated chromatin can lead to substantial chromosome rearrangements via chromothripsis. However, the molecular details of micronucleus-based chromothripsis are still unclear. Now, an elegant system that specifically induces missegregation of the Y chromosome provides insight into this process, including a role for non-homologous end joining.

Related Organizations

Fred Hutchinson Cancer Research Center
United States

Keywords

Chromothripsis, Chromosomes, Human, Y, DNA End-Joining Repair, Humans, Models, Biological, Chromatin, Micronuclei, Chromosome-Defective

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