descriptionPublicationkeyboard_double_arrow_right Article 27 May 2016 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 18, pages 593-594 (issn: 1465-7392, eissn: 1476-4679,

Authors: Christian Speck; Silvia Tognetti; Silvia Tognetti;

doi: 10.1038/ncb3367

pmid: 27230530

handle: 10044/1/33610

Replicating repetitive DNA

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Abstract

The function and regulation of repetitive DNA, the 'dark matter' of the genome, is still only rudimentarily understood. Now a study investigating DNA replication of repetitive centromeric chromosome segments has started to expose a fascinating replication program that involves suppression of ATR signalling, in particular during replication stress.

Related Organizations

Imperial College London
United Kingdom
Universitat Pompeu Fabra
Spain
MRC London Institute of Medical Sciences
United Kingdom

Keywords

DNA Replication, Centromere, 610, 11 Medical And Health Sciences, DNA, 06 Biological Sciences, Xenopus laevis, Animals, Humans, Developmental Biology, Repetitive Sequences, Nucleic Acid

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Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression
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