Name: Fumarate in DNA repair
Creator: Susan P, Lees-Miller
Keywords: Histones, 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, DNA Repair, Fumarates, Humans, Protein Processing, Post-Translational, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 28 Aug 2015 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 17, pages 1,096-1,097 (issn: 1465-7392, eissn: 1476-4679,

Authors: Susan P, Lees-Miller;

doi: 10.1038/ncb3232

pmid: 26316455

Fumarate in DNA repair

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Abstract

A new study suggests that fumarase, a metabolic enzyme normally associated with ATP production in mitochondria, is recruited to sites of DNA damage where it produces fumarate to inhibit histone demethylation and promote repair of DNA double strand breaks.

Related Organizations

University of Calgary
Canada

Keywords

Histones, DNA Repair, Fumarates, Humans, Protein Processing, Post-Translational

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