Actin shapes the autophagosome

descriptionPublicationkeyboard_double_arrow_right Article 28 Aug 2015 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 17, pages 1,094-1,096 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Petter, Holland; Anne, Simonsen;

doi: 10.1038/ncb3224

pmid: 26316454

Actin shapes the autophagosome

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Abstract

Compared with most intracellular vesicles, the autophagosome is formed by an unusual event of vesicle budding involving an elusive sequence of membrane expansions that ends with a double membrane vesicle. It is now shown that actin polymerization inside the forming autophagosome is a driving force for the expansion and assembly of a functional autophagosome.

Related Organizations

University of Oslo
Norway

Keywords

CapZ Actin Capping Protein, Actin Cytoskeleton, Phagosomes, Autophagy, Animals, Intracellular Membranes

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