Energy stress tames the Hippo pathway
Copyright policy )Energy stress tames the Hippo pathway
The kinase AMPK, a sensor of cellular energy stress, has been shown to oppose the growth-promoting activity of YAP, the transcriptional co-activator downstream of the Hippo signalling pathway. This finding may help to explain why the antidiabetic drug metformin, for which AMPK is a key effector, is linked to cancer-protective activity.
- University of California, Berkeley United States
YAP-Signaling Proteins, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Phosphoproteins, Metformin, Humans, Hypoglycemic Agents, Hippo Signaling Pathway, Phosphorylation, Energy Metabolism, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
YAP-Signaling Proteins, AMP-Activated Protein Kinases, Protein Serine-Threonine Kinases, Phosphoproteins, Metformin, Humans, Hypoglycemic Agents, Hippo Signaling Pathway, Phosphorylation, Energy Metabolism, Adaptor Proteins, Signal Transducing, Signal Transduction, Transcription Factors
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