Sliding filaments and mitotic spindle organization

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 16, pages 737-739 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Haifeng, Wang; Ingrid, Brust-Mascher; Jonathan M, Scholey;

doi: 10.1038/ncb3019

pmid: 25082196

Sliding filaments and mitotic spindle organization

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Abstract

Mitosis depends upon the action of the mitotic spindle, a subcellular machine that uses microtubules (MTs) and motors to assemble itself and to coordinate chromosome segregation. Recent work illuminates how the motor-driven poleward sliding of MTs - nucleated at centrosomes, chromosomes and on pre-existing MTs - contributes to spindle assembly and length control.

Related Organizations

University of California, Davis
United States

Keywords

Humans, Spindle Apparatus, Microtubules

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