SIK2 regulates insulin secretion

descriptionPublicationkeyboard_double_arrow_right Article 28 Feb 2014 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 16, pages 210-212 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Bengt-Frederik, Belgardt; Markus, Stoffel;

doi: 10.1038/ncb2925

pmid: 24576898

SIK2 regulates insulin secretion

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Abstract

Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.

Related Organizations

ETH Zurich
Switzerland

Keywords

Male, Insulin-Secreting Cells, Ubiquitin-Protein Ligases, Phosphotransferases, Animals, Female, Protein Serine-Threonine Kinases

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