Slipping past the spindle assembly checkpoint

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2013 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 15, pages 1,261-1,263 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Radhika, Subramanian; Tarun M, Kapoor;

doi: 10.1038/ncb2876

pmid: 24189515

Slipping past the spindle assembly checkpoint

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Abstract

Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.

Related Organizations

Rockefeller University
United States

Keywords

Humans, M Phase Cell Cycle Checkpoints, Spindle Apparatus, Signal Transduction

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