TSC on the peroxisome controls mTORC1

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2013 Switzerland English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 15, pages 1,135-1,136 (issn: 1465-7392, eissn: 1476-4679,

Copyright policy )Funded by:SNSF | TOR signaling and control...

Authors: Benjamin, D.; Hall, M. N.;

doi: 10.1038/ncb2849

TSC on the peroxisome controls mTORC1

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Abstract

mTOR is a central controller that integrates many inputs to regulate cell growth and ensure cellular homeostasis. The mTORC1 inhibitor TSC (tuberous sclerosis complex) on the peroxisome is found to inhibit mTORC1 in response to endogenous reactive oxygen species. Thus, mTOR may avoid confounding different inputs by sensing them at different cellular locations.

Country

Switzerland

Related Organizations

University of Basel
Switzerland

Keywords

Tuberous Sclerosis, TOR Serine-Threonine Kinases, Peroxisomes, Animals, Humans, Lysosomes, Models, Biological, Protein Binding

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