
doi: 10.1038/ncb2833
pmid: 23999616
Faithful genome segregation depends on the functions of the eukaryotic centromere, which is characterized by the histone variant CENP-A. Gene replacement in human cells and fission yeast has now been used to show how CENP-A biochemically encodes centromere identity, as well as reveal an unexpected role for CENP-B in centromere function.
Histones, Chromosomal Proteins, Non-Histone, Centromere, Schizosaccharomyces, Humans, Schizosaccharomyces pombe Proteins, Autoantigens, Centromere Protein A, Epigenesis, Genetic
Histones, Chromosomal Proteins, Non-Histone, Centromere, Schizosaccharomyces, Humans, Schizosaccharomyces pombe Proteins, Autoantigens, Centromere Protein A, Epigenesis, Genetic
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