Holding on to stemness

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2012 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 14, pages 450-452 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Justin D, Lathia; Jeremy N, Rich;

doi: 10.1038/ncb2498

pmid: 22552145

Holding on to stemness

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Abstract

The attachment of stem cells to specialized functional niches instructs stem cell maintenance, with loss of adhesion associated with differentiation driven by cell-intrinsic programs. Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche.

Related Organizations

Cleveland Clinic
United States
Cleveland Clinic Lerner Research Institute
United States

Keywords

Neural Stem Cells, Antigens, Neoplasm, Cell Adhesion, Animals

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