DNA breakage drives nuclear search
Copyright policy )DNA breakage drives nuclear search
The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.
- Baylor College of Medicine United States
Recombination, Genetic, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins, Cell Cycle Proteins, Chromosomes, Fungal, Protein Serine-Threonine Kinases, DNA Damage
Recombination, Genetic, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins, Cell Cycle Proteins, Chromosomes, Fungal, Protein Serine-Threonine Kinases, DNA Damage
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