Pik1-ing clathrin adaptors
Copyright policy )Pik1-ing clathrin adaptors
Clathrin adaptor proteins are essential for clathrin-coated vesicle biogenesis, yet the mechanisms governing their recruitment and interactions remain incompletely defined. The clathrin adaptors Gga and AP-1 are now shown to be recruited sequentially to the trans-Golgi network in two waves of clathrin coat assembly, coupled by Pik1-mediated phosphatidylinositol-4-phosphate synthesis. These findings reveal mechanistic insights into the functional and regulatory relationships between these clathrin adaptors.
- University of California, Berkeley United States
Adaptor Proteins, Vesicular Transport, Saccharomyces cerevisiae Proteins, Phosphatidylinositol Phosphates, 1-Phosphatidylinositol 4-Kinase, trans-Golgi Network
Adaptor Proteins, Vesicular Transport, Saccharomyces cerevisiae Proteins, Phosphatidylinositol Phosphates, 1-Phosphatidylinositol 4-Kinase, trans-Golgi Network
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