Shaping development with ESCRTs

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 22 Dec 2011 Italy English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 14, pages 38-45 (issn: 1465-7392, eissn: 1476-4679,

Copyright policy )Funded by:EC | PI3K-III COMPLEX

Authors: T. E. Rusten; T. Vaccari; H. Stenmark;

doi: 10.1038/ncb2381

pmid: 22193162

handle: 2434/491549

Shaping development with ESCRTs

- Summary
- Subjects
- Metrics

Abstract

Originally identified for their involvement in endosomal sorting and multivesicular endosome (MVE) biogenesis, components of the endosomal sorting complex required for transport (ESCRT) are now known to control additional cellular functions such as receptor signalling, cytokinesis, autophagy, polarity, migration, miRNA activity and mRNA transport. The diverse cell biological functions of ESCRT proteins are translated into a pleiotropic set of developmental trajectories that reflect the wide repertoire of these evolutionarily conserved proteins.

Country

Italy

Related Organizations

University of Milan
Italy
University of Oslo
Norway
Institute of Cancer Research
United Kingdom
FIRC Institute of Molecular Oncology
Italy
Oslo University Hospital
Norway

Keywords

Protein Transport, Endosomal Sorting Complexes Required for Transport, Animals; Endosomal Sorting Complexes Required for Transport; Humans; Multivesicular Bodies; Protein Transport; Cell Biology, Multivesicular Bodies, Animals, Humans

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	115
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%