α-catenin mechanosensing for adherens junctions

descriptionPublicationkeyboard_double_arrow_right Article 09 May 2010 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 12, pages 522-524 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Thomas, Lecuit;

doi: 10.1038/ncb2066

pmid: 20453846

α-catenin mechanosensing for adherens junctions

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Abstract

The balance of cohesion and remodelling is essential for the integrity and morphogenesis of epithelia. This requires adhesion and transmission of actomyosin tension, both of which are mediated by E-cadherin. The finding that actomyosin tension reinforces mechanical coupling of actin to E-cadherin through alpha-catenin reveals similarities with integrin regulation.

Related Organizations

Centre national de la recherche scientifique
France
Conférence des Présidents d'Université
France

Keywords

Integrins, Morphogenesis, Animals, Humans, Adherens Junctions, Cadherins, Actins, Cytoskeleton, Epithelium, alpha Catenin

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