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Nature Cell Biology
Article . 2008 . Peer-reviewed
License: Springer TDM
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Nature Cell Biology
Article . 2008
Data sources: Europe PubMed Central
https://dx.doi.org/10.1038/ncb...
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Under arrest in mitosis: Cdc20 dies twice

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2008 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 10, pages 1,385-1,387 (issn: 1465-7392, eissn: 1476-4679, Copyright policy )
Authors: Fry, AM; Yamano, H;

doi: 10.1038/ncb1208-1385

pmid: 19043431

handle: 2381/17741

Under arrest in mitosis: Cdc20 dies twice

Abstract

The spindle assembly checkpoint is crucial for maintaining genome integrity in dividing cells by preventing premature chromosome segregation. Degradation of the APC/C activator Cdc20 seems to be an essential and conserved mechanism to maintain this checkpoint in the presence of chromosomes that are not attached to the mitotic spindle.

Related Organizations
Keywords

Cdc20 Proteins, Calcium-Binding Proteins, Post-Translational, Mitosis, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Spindle Apparatus, Protein Serine-Threonine Kinases, Protein-Serine-Threonine Kinases, Mitotic Spindle Apparatus, Anaphase-Promoting Complex-Cyclosome, Repressor Proteins, Mad2 Proteins, Humans, Protein Processing, Post-Translational, Protein Processing, Protein Binding

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 23
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
23
Average
Top 10%
Top 10%
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