Cell fate in the Hand of Plk4

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2007 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 9, pages 1,127-1,129 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Marvin E. Tanenbaum; René H. Medemao;

doi: 10.1038/ncb1007-1127

Cell fate in the Hand of Plk4

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Abstract

The transcription factor Hand1 is required for cell-fate determination during placental development. Recent work shows that release of Hand1 from the nucleolus controls differentiation of trophoblast stem cells into trophoblast giant cells, and this switch is controlled by the antagonistic activities of HICp40 and Polo-like kinase-4 (Plk4).

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Utrecht University
Netherlands
University Medical Center Utrecht
Netherlands

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