Robo is Abl to block N-Cadherin function

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2002 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 4, pages E227-E229 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Mark M, Emerson; David, Van Vactor;

doi: 10.1038/ncb1002-e227

pmid: 12360300

Robo is Abl to block N-Cadherin function

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Abstract

The molecular pathways involved in wiring the brain have just begun to be elucidated. Work in this issue of Nature Cell Biology has uncovered inhibitory interactions between two such pathways: Roundabout (Robo) and N-Cadherin. This discovery provides a potential mechanistic understanding of how pathways are used in a coordinated manner to guide axons.

Related Organizations

Harvard University
United States

Keywords

Central Nervous System, Roundabout Proteins, Growth Cones, Cell Differentiation, Nerve Tissue Proteins, Cell Communication, Cadherins, Animals, Humans, Receptors, Immunologic, Proto-Oncogene Proteins c-abl, Signal Transduction

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