A sixth sense for Rab5

descriptionPublicationkeyboard_double_arrow_right Article 01 Jun 2005 English Publisher:Springer Science and Business Media LLCJournal:Nature Cell Biology, volume 7, pages 548-550 (issn: 1465-7392, eissn: 1476-4679,

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Authors: Alexander M. van der Bliek;

doi: 10.1038/ncb0605-548

A sixth sense for Rab5

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Abstract

It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.

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University of California, Los Angeles
United States

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