Name: Entrapment Vectors: A New Tool for Mammalian Genetics
Creator: W C, Skarnes
Keywords: 0301 basic medicine, Mice, 0303 health sciences, 03 medical and health sciences, Stem Cells, Genetic Vectors, Animals, 16. Peace & justice, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1990 English Publisher:Springer Science and Business Media LLCJournal:Nature Biotechnology, volume 8, pages 827-831 (issn: 1087-0156, eissn: 1546-1696,

Authors: W C, Skarnes;

doi: 10.1038/nbt0990-827

pmid: 1366793

Entrapment Vectors: A New Tool for Mammalian Genetics

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Abstract

The use of mouse embryonic stem (ES) cells has facilitated the creation of mouse strains carrying desired genetic alterations. Recently, "entrapment" vectors have been developed to identify and mutate genes active during embryogenesis. These vectors in combination with ES cells may provide an efficient screening strategy to find genes that control mouse development.

Related Organizations

Lunenfeld-Tanenbaum Research Institute
Canada
University of Toronto
Canada
Mount Sinai Hospital
Canada

Keywords

Mice, Stem Cells, Genetic Vectors, Animals

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