Chronic DLL4 blockade induces vascular neoplasms
Copyright policy )Chronic DLL4 blockade induces vascular neoplasms
Delta-like 4 (DLL4)-mediated Notch signalling has emerged as an attractive target for cancer therapy. However, the potential side effects of blocking this pathway remain uncertain. Here we show that chronic DLL4 blockade causes pathological activation of endothelial cells, disrupts normal organ homeostasis and induces vascular tumours, raising important safety concerns.
- GENENTECH INC United States
Receptors, Notch, Calcium-Binding Proteins, Intracellular Signaling Peptides and Proteins, Endothelial Cells, Membrane Proteins, Antineoplastic Agents, Vascular Neoplasms, Rats, Macaca fascicularis, Mice, Animals, Humans, Chemical and Drug Induced Liver Injury, Adaptor Proteins, Signal Transducing, Signal Transduction
Receptors, Notch, Calcium-Binding Proteins, Intracellular Signaling Peptides and Proteins, Endothelial Cells, Membrane Proteins, Antineoplastic Agents, Vascular Neoplasms, Rats, Macaca fascicularis, Mice, Animals, Humans, Chemical and Drug Induced Liver Injury, Adaptor Proteins, Signal Transducing, Signal Transduction
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