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doi: 10.1038/nature01107
pmid: 12368866
The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which to conduct comparative proteomics studies of this human pathogen. Here, we applied a high-throughput proteomics approach to identify new potential drug and vaccine targets and to better understand the biology of this complex protozoan parasite. We characterized four stages of the parasite life cycle (sporozoites, merozoites, trophozoites and gametocytes) by multidimensional protein identification technology. Functional profiling of over 2,400 proteins agreed with the physiology of each stage. Unexpectedly, the antigenically variant proteins of var and rif genes, defined as molecules on the surface of infected erythrocytes, were also largely expressed in sporozoites. The detection of chromosomal clusters encoding co-expressed proteins suggested a potential mechanism for controlling gene expression.
Male, Life Cycle Stages, Erythrocytes, Proteome, Plasmodium falciparum, Protozoan Proteins, Chromosomes, Antimalarials, Germ Cells, Malaria Vaccines, Animals, Humans, Female, Genome, Protozoan
Male, Life Cycle Stages, Erythrocytes, Proteome, Plasmodium falciparum, Protozoan Proteins, Chromosomes, Antimalarials, Germ Cells, Malaria Vaccines, Animals, Humans, Female, Genome, Protozoan
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 1K | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 0.1% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 0.1% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 0.1% |