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Kim-1/Tim-1 and immune cells: shifting sands

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2012 United States English Publisher:Elsevier BVJournal:Kidney International, volume 81, pages 809-811 (issn: 0085-2538, Copyright policy )
Authors: Ichimura, Takaharu; Brooks, Craig R.; Bonventre, Joseph;

doi: 10.1038/ki.2012.11

pmid: 22499138

pmc: PMC3339439

Kim-1/Tim-1 and immune cells: shifting sands

Abstract

Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression, understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.

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Keywords

CD4-Positive T-Lymphocytes, Male, Immunity, Cellular, 610, Membrane Proteins, Kidney, Lymphocyte Activation, Article, 618, Glomerulonephritis, Nephrology, Animals, Hepatitis A Virus Cellular Receptor 1

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 74
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
74
Top 10%
Top 10%
Top 10%
Green
hybrid