Intracellular cAMP signaling by soluble adenylyl cyclase
Copyright policy )Intracellular cAMP signaling by soluble adenylyl cyclase
Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.
- Scripps Institution of Oceanography United States
- University of California, San Diego United States
- Cornell University United States
- University of California, San Francisco United States
- Weill Cornell Medical College
Organelles, Cytoplasm, Protein Conformation, intracellular pH, Second Messenger Systems, Gene Expression Regulation, Enzymologic, Protein Structure, Tertiary, Isoenzymes, Bicarbonates, Structure-Activity Relationship, Nephrology, intracellular signal, Cyclic AMP, Animals, Humans, cyclic AMP, Calcium, Adenylyl Cyclases
Organelles, Cytoplasm, Protein Conformation, intracellular pH, Second Messenger Systems, Gene Expression Regulation, Enzymologic, Protein Structure, Tertiary, Isoenzymes, Bicarbonates, Structure-Activity Relationship, Nephrology, intracellular signal, Cyclic AMP, Animals, Humans, cyclic AMP, Calcium, Adenylyl Cyclases
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