Hyperphosphatemia of chronic kidney disease
Copyright policy )Hyperphosphatemia of chronic kidney disease
Observational studies have determined hyperphosphatemia to be a cardiovascular risk factor in chronic kidney disease. Mechanistic studies have elucidated that hyperphosphatemia is a direct stimulus to vascular calcification, which is one cause of morbid cardiovascular events contributing to the excess mortality of chronic kidney disease. This review describes the pathobiology of hyperphosphatemia that develops as a consequence of positive phosphate balance in chronic kidney disease and the mechanisms by which hyperphosphatemia acts on neointimal vascular cells that are stimulated to mineralize in chronic kidney disease. The characterization of hyperphosphatemia of chronic kidney disease as a distinct syndrome in clinical medicine with unique disordered skeletal remodeling, heterotopic mineralization and cardiovascular morbidity is presented.
- Washington State University United States
- University of Mary United States
- Washington University in St. Louis United States
- Shire plc Sweden
- Creighton University United States
Chronic Kidney Disease-Mineral and Bone Disorder, osteoblasts, Calcinosis, Syndrome, Phosphates, Hyperphosphatemia, renal osteodystrophy, vascular calcification, Nephrology, Cardiovascular Diseases, Chronic Disease, CKD, vascular smooth muscle cells, Humans, Osteoporosis, Kidney Diseases, phosphate
Chronic Kidney Disease-Mineral and Bone Disorder, osteoblasts, Calcinosis, Syndrome, Phosphates, Hyperphosphatemia, renal osteodystrophy, vascular calcification, Nephrology, Cardiovascular Diseases, Chronic Disease, CKD, vascular smooth muscle cells, Humans, Osteoporosis, Kidney Diseases, phosphate
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