Growth factors and cytokines such as the platelet-derived growth factor (PDGF) have the potential to mediate many biologic responses of glomerular cells, particularly mesangial cells [1]. Peptide growth factors including PDGF possess diverse biologic properties highly relevant to glomerular pathology [2]. Biologic effects of PDGF may include promotion of hypertrophy and proliferation, regulation of matrix metabolism, vasoactive properties, regulation of immune-inflammatory responses such as chemotaxis, activation or deactivation of inflammatory cells, and a role in development and differentiation.