BRAF and MC1R in Melanoma: Different in Head and Neck Tumors?
Copyright policy )BRAF and MC1R in Melanoma: Different in Head and Neck Tumors?
In this issue, Hacker et al. (2012) report the largest study to date on the association between MC1R variants and BRAF mutant melanoma. Although they did not observe a significant overall correlation, there was a significant negative association between BRAF and MC1R mutations for head/neck melanomas. This suggests a fundamental difference in pathogenesis between head/neck and truncal melanomas, which could contribute to their divergent prognoses.
- Harvard Medical School United States
- Harvard University United States
- Massachusetts General Hospital United States
Male, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Membrane Proteins, Cell Biology, Dermatology, Biochemistry, GTP Phosphohydrolases, Cutaneous Malignant Melanoma, Humans, Female, Molecular Biology, Melanoma, Receptor, Melanocortin, Type 1
Male, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Membrane Proteins, Cell Biology, Dermatology, Biochemistry, GTP Phosphohydrolases, Cutaneous Malignant Melanoma, Humans, Female, Molecular Biology, Melanoma, Receptor, Melanocortin, Type 1
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