SNPing at the Epidermal Barrier
Copyright policy )SNPing at the Epidermal Barrier
Filaggrin variants are well-established risk factors for atopic eczema (AE). Recent studies suggest additional epidermal differentiation complex (EDC) gene associations with AE. In this issue, Marenholz and colleagues confirm this prediction and show that a small proline-rich protein 3 (SPRR3) variant confers susceptibility to AE. This finding suggests that further genetic and functional characterization of SPRR3 should be performed in patients with AE.
- National Institutes of Health United States
- Queen Mary University of London United Kingdom
- University of London United Kingdom
- Blizard Institute United Kingdom
- National Cancer Institute United States
Cell Biology, Dermatology, Filaggrin Proteins, Biochemistry, Dermatitis, Atopic, Cornified Envelope Proline-Rich Proteins, Risk Factors, Humans, Genetic Predisposition to Disease, Epidermis, Molecular Biology
Cell Biology, Dermatology, Filaggrin Proteins, Biochemistry, Dermatitis, Atopic, Cornified Envelope Proline-Rich Proteins, Risk Factors, Humans, Genetic Predisposition to Disease, Epidermis, Molecular Biology
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