p63, a Story of Mice and Men
Copyright policy )p63, a Story of Mice and Men
The transcription factor p63 is essential for the formation of the epidermis and other stratifying epithelia. This is clearly demonstrated by the severe abnormality of p63-deficient mice and by the development of certain types of ectodermal dysplasias in humans as a result of p63 mutations. Investigation of the in vivo functions of p63 is complicated by the occurrence of 10 different splicing isoforms and by its interaction with the other family members, p53 and p73. In vitro and in vivo models have been used to unravel the functions of p63 and its different isoforms, but the results or their interpretation are often contradictory. This review focuses on what mammalian in vivo models and patient studies have taught us in the last 10 years.
- University of Rome Tor Vergata Italy
- Radboud University Nijmegen Medical Centre Netherlands
- Radboud University Nijmegen Netherlands
- University of Leicester United Kingdom
- Medical Research Council United Kingdom
Epidermi, Genotype, Dermatology, Biochemistry, Mice, Ectodermal Dysplasia, Neoplasms, Cell Adhesion, Animals, Humans, Membrane Protein, Molecular Biology, Settore BIO/11 - BIOLOGIA MOLECOLARE, Animal, Palate, Palate; Phosphoproteins; Mutation; Membrane Proteins; Phenotype; Neoplasms; Cell Adhesion; Animals; Genotype; Humans; Epidermis; Mice; Trans-Activators; Ectodermal Dysplasia; Extremities; Interferon Regulatory Factors, Membrane Proteins, Extremities, Cell Biology, NCMLS 6: Genetics and epigenetic pathways of disease DCN 2: Functional Neurogenomics, Phosphoproteins, Phenotype, Trans-Activator, Phosphoprotein, Interferon Regulatory Factors, Mutation, Trans-Activators, Neoplasm, Epidermis, Extremitie, Human
Epidermi, Genotype, Dermatology, Biochemistry, Mice, Ectodermal Dysplasia, Neoplasms, Cell Adhesion, Animals, Humans, Membrane Protein, Molecular Biology, Settore BIO/11 - BIOLOGIA MOLECOLARE, Animal, Palate, Palate; Phosphoproteins; Mutation; Membrane Proteins; Phenotype; Neoplasms; Cell Adhesion; Animals; Genotype; Humans; Epidermis; Mice; Trans-Activators; Ectodermal Dysplasia; Extremities; Interferon Regulatory Factors, Membrane Proteins, Extremities, Cell Biology, NCMLS 6: Genetics and epigenetic pathways of disease DCN 2: Functional Neurogenomics, Phosphoproteins, Phenotype, Trans-Activator, Phosphoprotein, Interferon Regulatory Factors, Mutation, Trans-Activators, Neoplasm, Epidermis, Extremitie, Human
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).159 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!