7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007

descriptionPublicationkeyboard_double_arrow_right Article 16 Mar 2016 English Publisher:Springer Science and Business Media LLCJournal:The Journal of Antibiotics, volume 69, pages 647-651 (issn: 0021-8820, eissn: 1881-1469,

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Authors: Ryuji, Uchida; Kento, Nakajyo; Keisuke, Kobayashi; Taichi, Ohshiro; Takeshi, Terahara; Chiaki, Imada; Hiroshi, Tomoda;

doi: 10.1038/ja.2016.27

pmid: 26980608

7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007

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Abstract

A new depsidone, named 7-chlorofolipastatin, and five known structurally related depsidones were isolated from the culture broth of the marine-derived fungus Aspergillus ungui NKM-007 by solvent extraction and HPLC using an octadecylsilyl column. The structure of 7-chlorofolipastatin was elucidated by various spectroscopic data including 1D and 2D NMR spectroscopy. 7-Chlorofolipastatin inhibited sterol O-acyltransferase (SOAT) 1 and 2 isozymes in cell-based and enzyme assays using SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells.

Related Organizations

Tokyo University of Marine Science and Technology
Japan
Kitasato University
Japan

Keywords

Magnetic Resonance Spectroscopy, CHO Cells, Depsides, Lactones, Aspergillus, Cricetulus, Sterol O-Acyltransferase 2, Cricetinae, Animals, Enzyme Inhibitors, Chromatography, High Pressure Liquid, Sterol O-Acyltransferase

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