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The Journal of Antibiotics
Article
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The Journal of Antibiotics
Article . 2011 . Peer-reviewed
License: Springer TDM
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The Journal of Antibiotics
Article . 2012
Data sources: Europe PubMed Central
https://dx.doi.org/10.1038/ja....
Article
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Newcastle University Library ePrints Service
Article . 2011
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Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38

descriptionPublicationkeyboard_double_arrow_right Article 19 Oct 2011 United Kingdom English Publisher:Springer Science and Business Media LLCJournal:The Journal of Antibiotics, volume 64, pages 775-780 (issn: 0021-8820, eissn: 1881-1469, Copyright policy )
Authors: Nachtigall J; Kulik A; Helaly S; Bull AT; Goodfellow M; Asenjo JA; Maier A; +4 Authors

doi: 10.1038/ja.2011.96

pmid: 22008702

Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38

Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A-C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.

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Keywords

Spectrometry, Mass, Electrospray Ionization, Molecular Structure, Mycelium, Antineoplastic Agents, Microbial Sensitivity Tests, Streptomyces, Cyclic Nucleotide Phosphodiesterases, Type 4, Cell Line, Tumor, Polyketides, Spectroscopy, Fourier Transform Infrared, Humans, Chile, Desert Climate, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Nuclear Magnetic Resonance, Biomolecular, Soil Microbiology

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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 68
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
68
Top 10%
Top 10%
Top 10%
bronze